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Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 361-373 doi: 10.1007/s11684-018-0656-6

Abstract: termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancerinvasiveness, drug-resistance and the ability to form metastases at distant organs, and thereby contribute to cancermetastasis and relapse.

Keywords： epithelial-to-mesenchymal transition     cancer     metastasis     cancer stem cell    

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Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervicalcancer

Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 106-112 doi: 10.1007/s11684-014-0307-5

Abstract: However, the molecular alterations that drive progression and metastasis of cervical cancer remain unclearCellular senescence has been proposed as the mechanism that protects an organism against cancer progressionand metastasis.transcription factor, has been suggested as an oncogene because it is overexpressed in many types of human cancercervical cancer.

Keywords： cervical cancer     senescence     Twist     CBX3     lymph node metastasis    

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Effect of atorvastatin on tumor growth and metastasis in a breast cancer cell xenograft model and its

Liu LIU MD, PhD, Yaogui NING MM, Chen CHEN MD, Daowen WANG MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 443-446 doi: 10.1007/s11684-009-0079-5

Abstract: paper aims to evaluate the effects and the possible mechanisms of atorvastatin on tumor growth and metastasisAt the end of the experiment, the tumor volume and weight and the lung metastasis colonies of each mouseAtorvastatin suppressed xenograft tumor growth and metastasis both in the low-dose and the high-doseThis suggests that atorvastatin has the efficacy of suppressing tumor growth and metastasis .

Keywords： atorvastatin     xenograft tumor     metastasis     CYP2J2    

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Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 57-62 doi: 10.1007/s11684-015-0389-8

Abstract:

The existence of cancer stem cells, stem-like cancer cells (SLCCs), or tumor-initiating cells is consideredOur previous research demonstrates that SLCCs are inducible by increasing genomic instability in cancer

Keywords： rabbit VX2 liver tumor     mitomycin C     AET     stem-like cancer cells     genomic instability    

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Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the

Frontiers of Medicine   Pages 924-938 doi: 10.1007/s11684-023-1004-z

Abstract: However, the potential mechanism by which lncRNAs affect the recurrence and metastasis of ovarian cancerand loss-of-function assays demonstrated that LOC646029 inhibits the proliferation, invasiveness, and metastasisof ovarian cancer cells in vivo and in vitro.Collectively, our results demonstrated that LOC646029 is involved in the progression and metastasis ofovarian cancer, which may be a potential prognostic biomarker.

Keywords： ovarian cancer     lncRNA LOC646029     metastasis     microRNA 627-3p     SPRED1    

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chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 93-104 doi: 10.1007/s11684-021-0892-z

Abstract: chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 stage IB–IIA) cervical canceradjuvant chemotherapy treatment showed non-inferior efficacy in patients with early-stage cervical cancer

Keywords： chemotherapy     cervical cancer     lymph node metastasis     concurrent chemoradiotherapy     quality of life    

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CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 204-211 doi: 10.1007/s11684-016-0443-1

Abstract: a tumor-associated carbohydrate epitope (glycotope) functionally involved in blood spread and liver metastasisof cancer cells by mediating the adhesion of cancer cells to endothelial cells and hepatocytes, respectivelyThe purified scFv can bind to the natural CD176 expressed on the surface of cancer cells.Furthermore, the CD176 scFv inhibits the adhesion of CD176+ cancer cells to endothelial

Keywords： CD176     Thomsen-Friedenreich antigen     scFv     cancer     therapy     adhesion     metastasis    

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Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer

Bo Zhou, Hongbin Xu, Meng Xia, Chaoyang Sun, Na Li, Ensong Guo, Lili Guo, Wanying Shan, Hao Lu, Yifan Wu, Yuan Li, Degui Yang, Danhui Weng, Li Meng, Junbo Hu, Ding Ma, Gang Chen, Kezhen Li

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 214-222 doi: 10.1007/s11684-017-0518-7

Abstract: Dysfunctional miR-9 expression remains ambiguous, and no consensus on the metastatic progression of ovarian cancerconfirmed that miR-9 could directly target this 3′-UTR. miR-9 and E-cadherin expression in ovarian cancerThe results showed that miR-9 was frequently upregulated in metastatic serous ovarian cancer tissue comparedThus, our study demonstrates that miR-9 may promote ovarian cancer metastasis via targeting E-cadherinand a novel potential therapeutic approach to control metastasis of ovarian cancer.

Keywords： ovarian cancer     metastasis     miR-9     E-cadherin    

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The Fibrillar Matrix: Novel Avenues for Breast Cancer Detection and Treatment Review

Rasha Rezk,  Raquel Marín-García,  Annica K.B.Gad

Engineering 2021, Volume 7, Issue 10,   Pages 1375-1380 doi: 10.1016/j.eng.2021.04.024

Abstract:

Breast cancer is marked by large increases in the protein fibers around tumor cells.microenvironment and can be used to understand how these cues regulate the growth and spread of breast cancerhow the stiffness and viscosity of the extracellular environment regulate cell migration and breast cancermetastasis.These models will guide the development of novel mechano-based therapies against breast cancer metastasis

Keywords： Breast cancer     Tissue stiffness     Cancer metastasis     Cell migration     Bioengineered scaffold     Viscosity    

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Bioinformatic exploration of MTA1-regulated gene networks in colon cancer

Chunxiao Li,Haijuan Wang,Feng Lin,Hui Li,Tao Wen,Haili Qian,Qimin Zhan

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 178-182 doi: 10.1007/s11684-016-0442-2

Abstract:

Metastasis-associated gene 1 (MTA1) controls a series of biological processes in tumor progressionThe global cancer gene regulatory network must be analyzed to determine the position of MTA1 in the molecularResults showed that in the development of colon cancer, MTA1 is linked to certain signal pathways, such

Keywords： metastasis-associated gene 1     colon cancer     bioinformatics    

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Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP-9, and COX-2 in breast cancer

Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 164-170 doi: 10.1007/s11684-009-0038-1

Abstract: The invasion and metastasis of breast cancer are supposed to involve several stages in which epithelial-mesenchymaltransition (EMT) is regarded as the mechanistic basis for the behavior of cancer cells.of breast cancer.metalloproteinase-9 (MMP-9), cyclooxygenase-2 (COX-2), and CD34 were examined in 74 cases of breast cancerin breast cancer.

Keywords： cell growth factor     matrix metalloproteinase-9     cyclooxygenase-2     higher microvascular density     breast cancer    

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Nanotechnology: A New Strategy for Lung Cancer Treatment Targeting Pro-Tumor Neutrophils Review

Jian Zhang, Shasha Jiang, Shilin Li, Jipeng Jiang, Jie Mei, Yandong Chen, Yongfu Ma, Yang Liu, Ying Liu

Engineering 2023, Volume 27, Issue 8,   Pages 106-126 doi: 10.1016/j.eng.2022.11.006

Abstract: There have also been reports that neutrophils can function as tumor promoters that contribute to lung cancerprogression and metastasis by influencing processes including carcinogenesis, angiogenesis, cancer cellproliferation, and invasion ability, as well as having similar roles in the lung metastasis of otherThe rapid development of nanotechnology has provided new strategies for cancer treatment targeting neutrophils

Keywords： Lung cancer     Metastasis     Neutrophils     Tumor microenvironment     Nanotechnology    

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Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 883-895 doi: 10.1007/s11684-022-0919-0

Abstract: Metastasis and drug resistance are the leading causes of poor prognosis in patients with osteosarcomaIdentifying the relevant factors that drive metastasis and drug resistance is the key to improving theKnockdown of Beclin1 and LC3B reduced invasion, metastasis, and proliferation in metastatic osteosarcoma and in vivo studies also demonstrated that inhibiting by 3-MA inhibited cell growth and metastasisautophagy-related genes were activated by SEs and that the inhibition of SEs by JQ-1 decreased the metastasis

Keywords： osteosarcoma     autophagy     metastasis     drug resistance     Beclin1     LC3B    

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Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 24-32 doi: 10.1007/s11684-014-0312-8

Abstract:

In this review, we summarize the novel findings from our series of studies on the leading metastasis-relatedgene expression profiling study, OPN was identified as one of the leading genes associated with the metastasisWe focused on OPN to evaluate its prognostic values and important roles in HCC metastasis.both in vitro and in vivoinvestigations, we found that OPN has an important role in metastasisand tumor growth of HCC and is an attractive potential therapeutic target for combating HCC metastasis

Keywords： osteopontin (OPN)     hepatocellular carcinoma     metastasis     prognosis     therapeutic target     biomarker     genetic    

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Exosomal CD44 Cooperates with Integrin α6β4 to Support Organotropic Metastasis via Regulating Tumor Cell Article

Wei Mu, Yajie Xu, Pengfei Gu, Wenbo Wang, Jingquan Li, Yang Ge, Hui Wang

Engineering 2021, Volume 7, Issue 10,   Pages 1415-1425 doi: 10.1016/j.eng.2020.08.013

Abstract:

Rapid metastasis to vital organs such as the lung, liver, and brain is responsible for the vast majorityof pancreatic cancer deaths.Liver metastasis of pancreatic cancer accounts for the high mortality rate in patients.Exosomes derived from pancreatic cancer cells tend to be enriched in proteins that are anchored to thestimulating the cytokines, proinflammatory factors, and growth factors that ultimately support tumor metastasis

Keywords： Pancreatic cancer     Organotropic metastasis     Exosomes     Pre-metastatic niche     CD44    

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Title Author Date Type Operation

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Journal Article

Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervicalcancer

Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang

Journal Article

Effect of atorvastatin on tumor growth and metastasis in a breast cancer cell xenograft model and its

Liu LIU MD, PhD, Yaogui NING MM, Chen CHEN MD, Daowen WANG MD, PhD,

Journal Article

Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng

Journal Article

Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the

Journal Article

chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer

Journal Article

CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Journal Article

Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer

Bo Zhou, Hongbin Xu, Meng Xia, Chaoyang Sun, Na Li, Ensong Guo, Lili Guo, Wanying Shan, Hao Lu, Yifan Wu, Yuan Li, Degui Yang, Danhui Weng, Li Meng, Junbo Hu, Ding Ma, Gang Chen, Kezhen Li

Journal Article

The Fibrillar Matrix: Novel Avenues for Breast Cancer Detection and Treatment

Rasha Rezk,  Raquel Marín-García,  Annica K.B.Gad

Journal Article

Bioinformatic exploration of MTA1-regulated gene networks in colon cancer

Chunxiao Li,Haijuan Wang,Feng Lin,Hui Li,Tao Wen,Haili Qian,Qimin Zhan

Journal Article

Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP-9, and COX-2 in breast cancer

Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG

Journal Article

Nanotechnology: A New Strategy for Lung Cancer Treatment Targeting Pro-Tumor Neutrophils

Jian Zhang, Shasha Jiang, Shilin Li, Jipeng Jiang, Jie Mei, Yandong Chen, Yongfu Ma, Yang Liu, Ying Liu

Journal Article

Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Journal Article

Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Journal Article

Exosomal CD44 Cooperates with Integrin α6β4 to Support Organotropic Metastasis via Regulating Tumor Cell

Wei Mu, Yajie Xu, Pengfei Gu, Wenbo Wang, Jingquan Li, Yang Ge, Hui Wang

Journal Article